Optics Search Talk
Monday, March 6, 2017, 12:00– 1:30 pm, in 489 Minor Hall
The Tracking Scanning Laser Ophthalmoscope (TSLO): Neurological Health Insights Via Eye-Tracking
Christy Sheehy, PhD
Postdoctoral Scholar at UCSF
Improved biomarkers that are capable of pre-symptomatically identifying patients with neurodegenerative disease, as well as objectively tracking patient progression and dysfunction, are desperately needed. Current clinical measures in neurology rely heavily on the use of expensive MRI brain scans and a physician’s time and expertise to examine a patient and their reported symptoms. Unlike most motor outputs that a clinician can test, eye movements have the potential to be quantitated at a scale not available to the current assessment of volitional movements using skeletal muscles in the limbs, head and trunk. Fixational eye movements are the finest recordable movements in the body and are under direct neurological control. Deficits of fixational eye movements have been described in a variety of neurological disorders, such as but not limited to: multiple sclerosis (MS), schizophrenia, Parkinson’s disease, Alzheimer’s disease (AD), traumatic brain injury (TBI) and concussion. Our goal is to clinically validate a retinal imaging and eyetracking technology, the tracking scanning laser ophthalmoscope (TSLO), as a prognostic and monitoring tool for neurodegenerative diseases and conditions.
During the first portion of my talk, I will showcase the design, build and characterization of the tracking scanning laser ophthalmoscope system and its flexibility of use. I will be highlighting its use as a retinal imaging and eye-tracking system, both monocular and binocular, as well as its capabilities to perform microperimetry and psychophysics. Additionally, I will show how the system can be used as an external tracker, guiding imaging beams for other high resolution systems such as optical coherence tomography (OCT) and adaptive optics scanning laser ophthalmoscopes (AOSLO).
The latter portion of my talk will focus on the TSLO system for use as a prognostic and monitoring tool for neurological health. This will include my current postdoctoral research work recording fixational eye motion at the UCSF Multiple Sclerosis Center, as well as my NIH funded C. Light Technologies research study for concussion screenings at the Sports Vision Institute here in Berkeley.
Host: Deborah Orel-Bixler