|AFFILIATIONS||Assistant Professor of Vision Science and Optometry|
Retinal Neurobiology and Neurophysiology
We are interested in how visual signals are encoded and transmitted by neurons in the healthy retina and how signaling is perturbed during the course of retinal degeneration. Ongoing projects in the lab are addressing the following questions:
To address these questions, we use a variety of research techniques including patch-clamp electrophysiology, immunohistochemistry, high-resolution imaging (confocal, super-resolution, electron and two-photon microscopy) and protein biochemistry.
Balakrishnan V, Puthussery T, Kim MH, Taylor WR, von Gersdorff H. Synaptic vesicle exocytosis at the dendritic lobules of an inhibitory interneuron in the mammalian retina. Neuron. 2015 87(3):563-575.
Gayet-Primo J. Puthussery T. Alterations in Kainate Receptor and TRPM1 Localization in Bipolar Cells after Retinal Photoreceptor Degeneration. Front Cell Neurosci. 2015. 9:486. doi: 10.3389/fncel.2015.00486. eCollection 2015
Puthussery T, Percival KA, Venkataramani S, Gayet-Primo J, Grünert U. Taylor, W.R. Kainate receptors mediate synaptic input to transient and sustained OFF visual pathways in primate retina. J Neurosci. 2014 34(22):7611-21. PMID: 24872565; PMCID: PMC4035522.
Puthussery T, Venkataramani S, Gayet-Primo J, Smith RG, Taylor WR. NaV1.1 channels in axon initial segments of bipolar cells augment input to magnocellular visual pathways in the primate retina. J Neurosci. 2013 33(41):16045-59. PMID: 24107939; PMCID: PMC3792449. *Feature Article, *Cover Illustration
Puthussery T, Gayet-Primo J, Pandey S, Duvoisin RM, Taylor WR. Differential loss and preservation of glutamate receptor function in bipolar cells in the rd10 mouse model of retinitis pigmentosa. Eur J Neurosci. 2009 (8):1533-42. PMID: 19385989; PMCID: PMC2818147.