Teresa Puthussery

350 Minor Hall
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AFFILIATIONS Assistant Professor of Vision Science and Optometry

Retinal Neurobiology and Neurophysiology

We are interested in how visual signals are encoded and transmitted by neurons in the healthy retina and how signaling is perturbed during the course of retinal degeneration. Ongoing projects in the lab are addressing the following questions:

  • How do retinal neurons extract specific features such as motion and spatial detail from the visual environment?
  • How do different types of neurotransmitter receptors and ion channels shape the response properties of retinal neurons?
  • How do mutations in the molecular machinery of cone-photoreceptors lead to retinal degeneration?
  • How does the structure and function of the inner retinal circuitry change in response to photoreceptor degeneration?

To address these questions, we use a variety of research techniques including patch-clamp electrophysiology, immunohistochemistry, high-resolution imaging (confocal, super-resolution, electron and two-photon microscopy) and protein biochemistry.

Selected publications

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Balakrishnan V, Puthussery T, Kim MH, Taylor WR, von Gersdorff H. Synaptic vesicle exocytosis at the dendritic lobules of an inhibitory interneuron in the mammalian retina. Neuron. 2015 87(3):563-575.

Gayet-Primo J. Puthussery T. Alterations in Kainate Receptor and TRPM1 Localization in Bipolar Cells after Retinal Photoreceptor Degeneration. Front Cell Neurosci. 2015. 9:486. doi: 10.3389/fncel.2015.00486. eCollection 2015

Puthussery T, Percival KA, Venkataramani S, Gayet-Primo J, Grünert U. Taylor, W.R. Kainate receptors mediate synaptic input to transient and sustained OFF visual pathways in primate retina. J Neurosci. 2014 34(22):7611-21. PMID: 24872565; PMCID: PMC4035522.

Puthussery T, Venkataramani S, Gayet-Primo J, Smith RG, Taylor WR. NaV1.1 channels in axon initial segments of bipolar cells augment input to magnocellular visual pathways in the primate retina. J Neurosci. 2013 33(41):16045-59. PMID: 24107939; PMCID: PMC3792449. *Feature Article, *Cover Illustration

Puthussery T, Gayet-Primo J, Pandey S, Duvoisin RM, Taylor WR. Differential loss and preservation of glutamate receptor function in bipolar cells in the rd10 mouse model of retinitis pigmentosa. Eur J Neurosci. 2009 (8):1533-42. PMID: 19385989; PMCID: PMC2818147.