Monday, October 24, 2016, 12:00– 1:30 pm, in 489 Minor Hall

Teenage Mutant Neuron Turtles: Slowed Axonal Degeneration is a Redox Process

presented by

Leonard A. Levin, MD, PhD
Affiliation: McGill University

 

Host: Austin Roorda

Abstract: Axonal injury is the common factor for virtually all optic neuropathies, including the most common cause of irreversible blindness world-wide, glaucoma. Injury to the axon causes functional loss of vision by interrupting axonal conduction, inducing dendritic retraction from afferent neurons in the retina, and initiating cell death processes in the retinal ganglion cell (RGC) soma. Irreversible changes occur when the RGC soma undergoes apoptosis and the axon degenerates. Preventing RGC soma apoptosis after axon injury is achievable, but our understanding of axonal degeneration limits the same for axonal degeneration. We have used ultrafast laser transection of RGC axons followed by detection of annexin binding to understand the regulation of injury-induced axonal degeneration. We have found that this process appears to be redox-dependent, and it can be slowed either genetically or chemically.

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