Friday, February 1912:00– 1:30 pm, in 489 Minor Hall

What have we learned about the pathophysiology and regulation of common inflammatory disorders of the cornea and ocular surface?

presented by

Reza Dana, MD, MPH, MSc

Claes Dohlman Professor of Ophthalmology, Harvard Medical School
Vice Chairman, Harvard Department of Ophthalmology
Director, Cornea & Refractive Surgery, Massachusetts Eye and Ear Infirmary
Director, Harvard Medical School Department of Ophthalmology Cornea Center of Excellence
Senior Scientist & W Clement Stone Scholar, Schepens Eye Research Institute

 


Abstract:
This talk will provide an overview of some of the key pathophysiologic mechanisms of corneal inflammation, angiogenesis, and transplant immunity. Cornea-specific regulatory mechanisms, such as those expressed by the corneal epithelium and resident immune cells, which maintain immune homeostasis will be emphasized. We will then provide survey of how chronic T cell-mediated autoimmunity and dry eye disease can subvert the normal homeostatic mechanisms that maintain immune quiescence by studying these factors in the context of corneal transplantation. Finally, we will provide overview of several novel strategies for augmenting immunoregulatory mechanisms, such as Treg expansion and use of tolerogenic antigen-presenting cells.

Host: Lu Chen

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