|AFFILIATIONS||Professor of Vision Science and Optometry|
Molecular mechanisms for eye development and disease
Research in the lab has been directed to study molecular and cellular mechanisms that control vertebrate organgenesis and diseases, mainly, the eye development and ocular diseases, by a combination of both basic and clinical methods with multidiscipline techniques from the fields of molecular and cellular biology, genetics, biochemistry, and electrophysiology etc. We are particularly interested in theidentification and characterization of novel genetic factors that play essential roles in the development of the eye as well as in pathological process of diseases like retinal degeneration, vascular disorders, and cataracts, etc. Ultimately, we’d like to develop additional biological and/or chemical tools to diagnose, prevent and/or cure related human eye diseases.
Xia CH, Liu H, Cheung D, Cheng C, Wang E, Du X, Chang B, Beutler B, Lo WK, Gong X. (2006) Diverse gap junctions modulate distinct mechanisms for fiber cell formation during lens development. Development 133, 2033-40. (Cover paper)
Dunia I, Cibert C, Gong X, Xia CH, Recouvreur M, Levy E, Kumar N, Bloemendal H, and Benedetti EL. (2006) Structural and immunocytochemical alterations in eye lens fiber cells from Cx46 and Cx50 knock-out mice Euro. J of Cell Biology 85(8):729-52.
Xia CH, Cheng C, Cheung D, Huang Q, Dunia I, Benedetti LE, Horwitz J, Gong X. (2006) Absence of gap junction channels lead to cataractogenesis by reducing g-crystallin. Experimental Eye Research 83, 688-96.
Xia CH, Chang B, Cheung D, Liu H, Wang M, Huang Q, Horwitz J, Gong X. (2006) Arginine 54 and tyrosine 118 residues of aA-crystallin are crucial for its roles in lens formation and transparency. Investigative Ophthalmology & Visual Science (IOVS) 47, 3004-10.
Xia CH, Cheung D, DeRosa AM, Chang B, Lo WK, White TW, Gong X. (2006) Knockin a3 (Cx46) connexin prevents severe cataracts caused by an a8 (Cx50)-G22R mutation. J Cell Science 119. 2138-44.
Xia CH, Liu H, Wang M, Cheung D, Park A, Yang Y, Du X, Chang B, Beutler B, Gong X. (2006) Retinal Degenerative Diseases edited by Hollyfield JG, Anderson RE, and LaVail MM. New York. Chapter 16, Characterization of mouse mutants with abnormal RPE cells. p95-100.
Liu H, Du X, Wang M, Huang Q, Ding L, McDonald HW, Yates, JR, Beutler B, Horwitz J, Gong X. (2005) Crystallin gammaB-I4F mutant protein binds to alpha-crystallin and affects lens transparency. Journal of Biological Chemistry 280, 25071-8
Shentu X, Yao K, Xu W, Zheng S, Hu S, Gong X. (2004) Special fasciculiform cataract caused by a mutation in the gammaD-crystallin gene. Molecular Vision. 10:233-9.
Sandilands A, Wang X, Hutcheson AM, James J, Prescott AR, Wegener A, Pekny M, Gong X, Quinlan RA. (2004) Bfsp2 mutation found in mouse 129 strains causes the loss of CP49 and induces vimentin-dependent changes in the lens fibre cell cytoskeleton. Experimental Eye Research 78: 109-23.
Du X, Tabeta K, Hoebe K, Liu H, Mann N, Mudd S, Crozat K, Sovath S, Gong X, Beutler B. (2004) Velvet, a dominant Egfr mutation that causes wavy hair and defective eyelid development in mice. Genetics. 166:331-40.
Gao J, Sun X, Martinez-Wittinghan FJ, Gong X, White TW and Mathias RT. (2004) Connections between connexins, calcium, and cataracts in the lens. J. Gen. Physiol. 124:1-12, 2004. (Cover paper)
Martinez-Wittinghan F.J., Sellitto C, Li L, Gong X, Brink PR, Mathias RT, White TW. (2003) Dominant cataracts result from incongruous mixing of wild-type lens connexins. J Cell Biology 161: 969-78. (Cover paper)