New Paper from the Puthussery-Taylor Lab

By Liza Shevchuk

About the Photo

Immunolabeled retinal section highlighting an amacrine cell type (arrows) involved in night vision.
Drs. Teresa Puthussery and Rowland Taylor have published a new paper in the journal Cell Reports. The paper is titled, Calcium-permeable AMPA receptors on AII amacrine cells mediate sustained signaling in the On-pathway of the primate retina.

Summary

Prior studies in human retinas have revealed clear asymmetries in the contrast response properties of ON- versus OFF-type ganglion cells. ON-ganglion cells can reliably signal both light increments and decrements whereas OFF-type ganglion cells are more skewed towards signaling light decrements. This study shows that the night vision pathway is important for generating these functional asymmetries. The results advance understanding of normal ganglion cell function and reveal a possible avenue for suppressing abnormal activity that develops in ganglion cells after photoreceptor degeneration.

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