Yue (Maria) Liu, OD, PhD
The Pamela P. Fong Faculty Chair in Optometry & Health Care
About Dr. Liu
Dr. Liu is a Professor of Clinical Optometry at UC Berkeley. She holds the Pamela P. Fong Faculty Chair in Optometry & Health Care. The emphasis of her research and clinical expertise is the investigation and utilization of novel contact-lens designs and pharmaceuticals in myopia control. She is the founder of the Myopia Control Clinic, the first of its kind in a teaching clinic; it now serves as a model for optometry schools across the country. Originally from Beijing, Liu practiced as an ophthalmologist in China before relocating to the US in 2000. She obtained her MBA prior to her OD training at Pacific University, College of Optometry. She also completed an MPH and a PhD at UC Berkeley.
Research Areas
Optical Control of Myopia Progression
Teaching
OPT 226A&B. General and Ocular Pharmacology
Instructor-in-Charge
Basic pharmacology, terminology, and concepts (both pharmacodynamic and pharmacokinetic) and pharmacotheraphy of medical conditions commonly encountered in clinical optometric practice (including cardiovascular disease, respiratory disease, diabetes, infection and inflammatory conditions, as well as central nervous system disorders).
OPT 213: Evidence-based Optometry
Instructor-in-Charge
This course covers (i) basic concepts of evidence-based medical practice with special reference to eye and/or vision care, (ii) fundamental biostatistics and epidemiological study designs with the focus on the concepts essential to understand the quality of evidence, (iii) strength of evidence on disease diagnosis, prognosis, therapy, and risk, (iv) resources to identify current best evidence.
OPT 260A: Contact Lenses – Examination of the Contact Lens Patient
Contributing Instructor
VS 215: Vision System Development
Contributing Instructor
Selected Publications
Alanazi, M.K.; Alshehri, M.; Althomali, M.; Liu, M. Choroidal response to optical defocus as a potential surrogate marker for myopia control. Accepted by Internal Journal of Ophthalmology, May 2025.
Ting Wang, Xiaoqin Chen, Mengdi Li, Hua Bi, Xiaoyan Yang, Muhan Sun, Yue Liu, Lihua Li, Bin Zhang. A Novel Model for Cornea Power Shift in Eyes Wearing Orthokeratology Lenses With Different Back Optic Zone Diameters for Myopia Control. Invest. Ophthalmol. Vis. Sci. 2025; 66(3):29. https://doi.org/10.1167/iovs.66.3.29
Alanazi, M.K.; Almansour, A.; Almutairi, S.S.; Alharbi, A.; Alhazmi, M.S.; Almustanyir, A.; Altoaimi, B.H.; Almutairi, M.S.; Alamri, M.M.; Liu, M. Evaluation of Static and Dynamic Pupil and Light Sensitivity to a Single Drop of Various Concentrations of Low-Dose Atropine (0.01%, 0.025%, and 0.05%). Life 2025, 15, 278. https://doi.org/10.3390/life15020278
X. Chen, Y. Guo, H. Bi, X. Liu, Y. Wu, T. Wang, L. Li, W. Lu, M. Liu, Y. Wang. The Impact of Back Optic Zone Design in Orthokeratology on Visual Performance. Trans. Vis. Sci. Tech. 2024; 13(5):12. https://doi.org/10.1167/tvst.13.5.12
Z. Liu, M. Liu, et al. Retinal and Choroidal Structural and Vascular Changes of Emmetropes and Myopes in Chinese Children. Ophthalmic and Physiological Optics, 2024. http://doi.org/10.1111/opo.13291
M. Alanazi, P. Caroline, A. Alshamrani, M. Liu. Impact of multifocal gas-permeable lens designs on short-term choroidal response, axial length, and retinal defocus profile. Int J Ophthalmol, 2024; 17(2):247–256.
M. Holmes, M. Liu, S. Singh. Retrospective analysis of axial length changes in overnight orthokeratology in an academic myopia clinic. Accepted by OVS, Jul 27, 2023.
M. Bullimore, M. Liu. Efficacy of the Euclid orthokeratology lens in slowing axial elongation. Contact Lens and Anterior Eye, 2023; 101875. ISSN 1367-0484. https://doi.org/10.1016/j.clae.2023.101875
Alanazi, M.; Almutleb, E.S.; Badawood, Y.S.; Kudam, M.A.; Liu, M. Perspectives and clinical practices of optometrists in Saudi Arabia concerning myopia in children. Int J Ophthalmol. 2023 Feb 18; 16(2):267–273. https://doi.org/10.18240/ijo.2023.02.14. PMID: 36816204; PMCID: PMC9922639
Alanazi, M.; Caroline, P.; Alshamrani, A.; Alanazi, T.; Liu, M. Visual Performance with Multifocal Corneal Gas-Permeable Contact Lenses in Young Adults: A Pilot Study. J Optom. 2022 Oct–Dec; 15(4):305–312. https://doi.org/10.1016/j.optom.2022.01.001
Alanazi, M.; Caroline, P.; Alshamrani, A.; Alanazi, T.; Liu, M. Regional Distribution of Choroidal Thickness and Diurnal Variation in Choroidal Thickness and Axial Length in Young Adults. Clin Ophthalmol. 2021; 15:4573–4584. https://doi.org/10.2147/OPTH.S334619
Contributing author. IMI – Prevention of Myopia and its Progression. IOVS, April 2021; Vol. 62(6). https://doi.org/10.1167/iovs.62.5.6
Contributing author. IMI – Clinical Management Guidelines Report. IOVS, February 2019; Vol. 60: M184–M203. https://doi.org/10.1167/iovs.18-25977
Y. Zhang, Y. Liu, Y. Hang, et al. Differential gene expression of BMP2 and BMP receptors in chick retina and choroid induced by imposed optical defocus. Visual Neuroscience, 2016, Nov 28. Epub.
T. Aller, Y. Liu, C. Wildsoet. Myopia control with bifocal contact lenses: a randomized clinical trial. Optom Vis Sci. 2016 Jan 18. Epub.
Y. Liu, P. Xie. Safety of orthokeratology – a systematic review. Eye and Contact Lens. 2016 Jan; 42(1):35–42.
Y. Zhang, Y. Liu, C. Ho, C.F. Wildsoet. Effects of imposed defocus of opposite sign on temporal gene expression patterns of BMP4 and BMP7 in chick RPE. Experimental Eye Research, 2013. https://doi.org/10.1016/j.exer.2013.02.010
Y. Liu, C.F. Wildsoet. The effective add inherent in 2-zone negative lenses inhibits eye growth in young chicks. IOVS, 2012 Jul; 53(8):5085–93.
Y. Zhang, Y. Liu, C.F. Wildsoet. Bidirectional, Optical Sign-Dependent Regulation of BMP2 Gene Expression in Chick Retinal Pigment Epithelium. IOVS, 2012 Sep; 53(10):6072–80.
L. Ostrin, Y. Liu, V. Choh, C.F. Wildsoet. The role of iris in chick accommodation. IOVS, 2011 Jul 1; 52(7):4710–6.
Y. Liu, C.F. Wildsoet. The effect of 2-zone concentric bifocal spectacle lenses on refractive error development and eye growth in young chicks. IOVS, 2010 Sep. https://doi.org/10.1167/iovs.10-XXXX (Add actual DOI if needed)
I. Vedamurthy, W. Harrison, Y. Liu, I. Cox, C.M. Schor. The influence of first near-spectacle reading correction on accommodation and its interaction with convergence. IOVS, 2009 Sep; 50(9):4215–22.