Jazzi Junge and Patrick Carney
Monday, October 15, 2018
11:10 am - 12:30 pm
489 Minor Hall
Quantifying Visual Functions in Children with Cerebral Visual Impairment (CVI)
Abstract: Patients with cerebral visual impairment (CVI) have vision loss resulting from an insult to the brain rather than to ocular structures. Our studies were aimed at understanding the effect of contour interaction (a component of crowding) in children with CVI. Furthermore, we compared measurements of visual acuity in the presence of contour interaction with the Cardiff Visual Acuity Test - a commonly used pediatric test. Finally, the effect of contour interaction between children with CVI and children with retinal disease was compared. The overarching goal of these studies is to translate measurements into usable interventions to improve the lives of patients with CVI.
Exploring Sex Dependent Molecular Drivers of Myopic Progression
Abstract: Myopia, or nearsightedness, is a visual condition that causes distant objects to appear out-of-focus. Its importance, as a major public health concern, is often underestimated. In large part this owes to our ability to correct optically for refractive errors with both glasses and contact lenses. Less appreciated is the fact that myopia is one of the leading causes of acquired legal blindness worldwide, via the induction of secondary pathologies. In addition to simply inducing refractive errors, the eye of myopic patients physically enlarges, elongating axially. This axial enlargement is driven by remodeling, thinning and expansion of the sclera, which in turn, disproportionately places myopes at an elevated risk of developing secondary blinding ocular pathologies. Interestingly, rates of myopia across the sexes vary. Women experience the condition at higher rates and, on average, with greater severity. And the condition seems to progress fastest around puberty. These observations indicate that sex dependent endocrine regulation may play a role in myopia development. In this talk we’ll explore the link between myopic progression, sex and molecular drivers of the pathology. More specifically we’ll explore how sex dependent endocrine regulation may play a role in myopic progression.