I specialize in diseases of the immune system and work to identify genetic factors that predispose people to autoimmune diseases and that modulate disease expression and clinical progression.
Most of my research to date has centered on multiple sclerosis. I and my colleagues at the University of California, San Francisco have recently initiated new studies focused on systemic lupus erythematosus, rheumatoid arthritis, and other autoimmune conditions. I am also investigating environmental exposures, such as smoking and maternal-fetal relationships.
My research interests can be categorized into five general areas: (a) comprehensive studies of major histocompatibility complex (MHC) variation in autoimmune disease, (b) full characterization of the autoimmune-prone multiple sclerosis phenotype and associated risk factors, (c) characterization of parent-of-origin and maternal-child immunogenetic relationships in autoimmunity, (d) population-based studies of genetic, social and environmental risk factors in autoimmune disease, and (e) application of novel analytical methodology to characterize gene-gene and gene-environment relationships in autoimmunity.
Bronson PG, Criswell LA, Barcellos LF. The MHC2TA -168A/G polymorphism and risk for rheumatoid arthritis: a meta-analysis of 6,861 patients and 9,270 controls reveals no evidence for association. Ann Rheum Dis. 2007 Sep 17; [Epub ahead of print]
International Multiple Sclerosis Genetics Consortium, Hafler DA, Compston A, Sawcer S, Lander ES, Daly MJ, De Jager PL, de Bakker PI, Gabriel SB, Mirel DB, Ivinson AJ, Pericak-Vance MA, Gregory SG, Rioux JD, McCauley JL, Haines JL, Barcellos LF, Cree B, Oksenberg JR, Hauser SL. Risk alleles for multiple sclerosis identified by a genomewide study. N Engl J Med. 2007 Aug 30;357(9):851-62. Epub 2007 Jul 29.
Weng X, Liu L, Barcellos LF, Allison JE, Herrinton LJ. Clustering of inflammatory bowel disease with immune mediated diseases among members of a northern california-managed care organization. Am J Gastroenterol. 2007 Jul;102(7):1429-35. Epub 2007 Apr 16.
Barcellos LF, Kamdar B, Ramsay PP, DeLoa C, Lincoln R, Caillier S, Schmidt S, Haines JL, Pericak-Vance MA, Oksenberg JR, Hauser SL (2006). Clustering of autoimmune diseases in high risk for multiple sclerosis families. The Lancet Neurology 5:924-931.
Barcellos LF, Sawcer S, Ramsay PP, Baranzini SE, Thomson G, Briggs F, Cree BCA, Begovich AB, Villoslada P, Montalban X, Ucelli A, Savettieri G, Lincoln RR, DeLoa C, Haines JL, Pericak-Vance, MA, Compston A, Hauser SL, Oksenberg JR (2006). Heterogeneity at the HLA-DRB1 locus and risk for multiple sclerosis. Human Molecular Genetics 15:2813-2824.
Burwick RM, Ramsay PP, Haines JL, Hauser SL, Oksenberg JR, Pericak-Vance MA, Schmidt S, Compston A, Sawcer S, Cittadella R, Savettieri G, Quattrone A, Polman CH, Uitdehaag BMJ, Zwemmer JNP, Hawkins CP, Ollier WER, Weatherby S, Enzinger C, Fazekas F, Schmidt H, Schmidt R, Hillert J, Masterman T, Hogh P, Niino M, Kikuchi S, Maciel P, Santos M, Rio ME, Kwiecinski H, Zakrzewska-Pniewska B, Evangelou N, Palace J, Barcellos LF (2006). APOE epsilon variation in multiple sclerosis susceptibility and disease severity: some answers. Neurology 66:1373-1383.
Traherne JA, Barcellos LF*, Sawcer SJ, Compston A, Ramsay PP, Hauser SL, Oksenberg JR, Trowsdale J (2006). Association of the truncating splice site mutation in BTNL2 with multiple sclerosis is secondary to HLA-DRB1*15. Human Molecular Genetics 15:155-161. *Co-first author.
Sawcer S, Ban M, Maranian M, Yeo TW, Compston A, Kirby A, Daly MJ, De Jager PL, Walsh E, Lander ES, Rioux JD, Hafler DA, Ivinson A, Rimmler J, Gregory SG, Schmidt S, Pericak-Vance MA, Akesson E, Hillert J, Datta P, Oturai A, Ryder LP, Harbo HF, Spurkland A, Myhr KM, Laaksonen M, Booth D, Heard R, Stewart G, Lincoln R, Barcellos LF, Hauser SL, Oksenberg JR, Kenealy SJ, Haines JL (2005). International Multiple Sclerosis Genetics Consortium. A high-density screen for linkage in multiple sclerosis. American Journal of Human Genetics 77:454-467.
Barcellos LF, Begovich AB, Reynolds RL, Caillier SJ, Brassat D, Schmidt S, Grams SE, Walker K, Steiner LL, Cree BA, Stillman A, Lincoln RR, Pericak-Vance MA, Haines JL, Erlich HA, Hauser SL, Oksenberg JR (2004). Evidence for linkage and association to NOS2A in multiple sclerosis. Annals of Neurology 6:793-800.
Oksenberg JR, Barcellos LF, Cree BAC, Baranzini SE, Bugawan TL, Khan O, Lincoln RR, Swerdlin A, Mignot E, Lin L, Goodin D, Erlich HA, Schmidt S, Thomson G, Reich DE, Pericak-Vance MA, Haines JL, Hauser SL (2004). Mapping multiple sclerosis susceptibility to the HLA-DR locus in African Americans. American Journal of Human Genetics 74:160-167.
Barcellos LF, Oksenberg JR, Begovich AB, Martin ER, Schmidt S, Vittinghoff E, Goodin DS, Pelletier D, Lincoln RR, Bucher P, Swerdlin A, Pericak-Vance MA, Haines JL, Hauser SL (2002). HLA-DR2 dose effect on susceptibility to multiple sclerosis and influence on disease course. American Journal of Human Genetics 72:710-716.
Barcellos LF, Oksenberg JR Green AJ, Bucher P, Rimmler JB, Schmidt S, Garcia ME, Lincoln RR, Pericak-Vance MA, Haines JL, Hauser SL (2002). Genetic basis for clinical expression in multiple sclerosis. Brain 125:150-158.
Schmidt S, Barcellos LF, DeSombre K, Rimmler JB, Lincoln RR, Bucher P, Saunders AM, Lai E, Martin ER, Vance JM, Oksenberg JR, Hauser SL, Pericak-Vance MA, Haines JL; Multiple Sclerosis Genetics Group (2002). Association of polymorphisms in the apolipoprotein E region with susceptibility to and progression of multiple sclerosis. American Journal of Human Genetics 70:708-717.
Barcellos LF, Caillier S, Dragone L, Elder M, Vittinghoff E, Bucher P, Lincoln RR, Pericak-Vance MA, Haines, JL, Weiss A, Hauser SL, Oksenberg JR (2001). PTPRC (CD45) is not associated with the development of multiple sclerosis in U.S. patients. Nature Genetics 29:23-24.
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