Monday, October 10, 2016, 12:00– 1:30 pm, in 489 Minor Hall

How the three photoreceptor pathways influence refractive eye growth and myopia

presented by

Machelle Pardue, PhD
Affiliation: Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University School of Medicine, Atlanta, GA and Atlanta VA Center for Visual and Neurocognitive Rehabilitation, Decatur, GA

 

Host: Austin Roorda

Abstract:

The retinal pathways that detect visual input and initiate the signaling for refractive eye growth are unknown. We evaluated the potential influence of the three types of photoreceptor pathways: rods, cones, and intrinsically photosensitive retinal ganglion cells (ipRGCs) by evaluating refractive development in mice with mutations in these pathways. We measured refractive error, corneal curvature and ocular parameters under normal laboratory conditions and in response to form deprivation in mice with non-functional rods (Gnat1-/-), cones (Gnat2-/-), or ipRGCs (Opn4-/-) and compared the data to wild-type (WT) age-matched controls. Our findings suggest that photoreceptor pathways may differentially influence refractive development. Disruption of rod or ipRGC pathways appeared to significantly alter refractive development under normal and FD conditions. Surprisingly, disrupted cone pathways which are needed for high acuity vision in primates did not affect refractive development under normal conditions and had minimal effects on the response to FD. We will discuss the potential role of dopamine as a stop signal for refractive eye growth and its regulation by these pathways.

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